Care was taken to form groups balanced in terms of the students' educational background. This encouraged students to help one another.

All students

Inês De Santiago Domingos De Jesus

“If your point of view is correct, each organism will be characteristized by a long number written in quadrucal (?) system with figures 1, 2, 3, 4 standing for different bases ... This would open a very exciting possibility of theoretical research based on combinatorix [sic] and the theory of numbers! ... I have a feeling this can be done. What do you think?” — George Gamow, in a letter to Watson and Crick (1953) (2012-02-02)


I obtained my degree in Biochemistry at Faculdade de Ciencias, University of Lisbon, in 2006. Inspired by my belief on the importance of the interdisciplinary integration of scientific knowledge, I joined the "PhD program in Computational Biology" at Instituto Gulbenkian de Ciencia, Portugal, in September 2006. I have finished my PhD in Dr Ana Pombo's lab at Medical Research Council, Imperial College London, United Kingdom, in 2011. Currently, I work as a post-doc in MRC, London, UK in the field of Embryonic Stem Cell Biology and Epigenomics, particulary analyzing Next Generation Sequencing data.

PhD Project

Supervisor: Ana Pombo

Cosupervisor: Marie-France Sagot

Laboratory: Genome Function Group

University: Imperial College London


Interplay between polycomb repression and RNA polymerase II regulation genome-wide in murine ES cells. Imperial College London (2012) pp.281. [pdf]


Ines de Santiago, Emily Brookes, Daniel Hebenstreit, Kelly J. Morris, Tom Carroll, Sheila Q. Xie, Julie K. Stock, Martin Heidemann, Dirk Eick, Naohito Nozaki, Hiroshi Kimura, Jiannis Ragoussis, Sarah A. Teichmann and Ana Pombo. . Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs. Cell Stem Cell (2012) 10 (2), 157-170.

M Madan Babu, Sarath Chandra Janga, Ines de Santiago, Ana Pombo. Eukaryotic gene regulation in three dimensions and its impact on genome evolution. Curr Opin Genet Dev (2008) 18(6), 571-582.