Care was taken to form groups balanced in terms of the students' educational background. This encouraged students to help one another.

All students

Bruno Emanuel Ferreira De Sousa Correia

The PDBC was an wonderfull experience. I had the opportunity of knowing a wide diversity subjects. In this program I had the chance of learning from people with very different backgrounds always with the ultimate aim of perform the cross-talk between different areas. This cross-talk allows the integration of different sorts of information in order to achieve knowledge that would be impossible to have without this kind of approach. Most of the times, the lecturers are some of the best in the on their research fields and their backgrounds can be very distinct: Computer Sciences, Mathematics, Physics, Biology, Chemistry, several Engineering's, etc. The IGC provides fantastic conditions that allowed all this to happen. The IGC has a very strong experimental component, and a fast-growing community of theoretical research groups and people interested in the potential of computational biology, so it is providing fantastic conditions to a program like this. The open-minded attitude that is present at the IGC provides a unique environment to learn what science is all about and to prepare the choice of a good PhD project. Additionally, Oeiras is a very pleasent place to live were it is possible to be close to the beach and simultaneously being close to a big city like Lisbon where you can find all kinds of amusements. (2005-12-01)

Resumé

Currently, I'm a Research Associate at the Cravatt Lab, Scripps Research Institute, La Jolla

I'm originally from a small town near Coimbra called Miranda do Corvo and I was born in 1980. In 2004, I completed the Chemistry degree at the Universidade de Coimbra. In two different occasions I was a research intern at the Warwick University-UK, firstly under the Socrates-Erasmus program and secondly with a Leonardo da Vinci scolarship. My scientific activity was mainly focus in proteins related with amyloid diseases and in protein-lipid interactions. During my first research projects I had the opportunity to work both on a wet laboratory and also with computational tools for protein structural modeling. My thesis projects were supervised by David Baker and Bill Schief at the University of Washington in Seattle. I completed my PhD in four years and my degree was granted by the Instituto de Tecnologia Quimica e Biologica-Universidade Nova de Lisboa. In my thesis research work I applied and developed several computational methods to design novel functional proteins. My current interests are related with protein structure prediction and protein-protein interactions. About my personal interests I am a music appreciator and I'm also interested in cinema, theatre and books. Other interests are related to several kinds of sports activities.

PhD Project

Supervisor: David Baker

Cosupervisor: Bill Schief

Laboratory: Baker Lab

University: University of Washington

Thesis

Computational design with flexible backbone sampling for protein remodeling and scaffolding of complex binding sites. Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa (2010) pp.162. [pdf]

Publications

Correia BE, Ban YEA, Friend DJ, Ellingson K, Xu HY, Boni E, Bradley-Hewitt T, Bruhn-Johannsen JF, Stamatatos L, Strong RK, and Schief WR . Computational Protein Design Using Flexible Backbone Remodeling and Resurfacing: Case Studies in Structure-Based Antigen Design. J Mol Biol (2011) 405, 284-297.

McLellan JS, Correia BE, Chen M, Yang Y, Graham BS, Schief WR, Kwong PD. Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus. J Mol Biol (2011) 409, 853-66.

Azoitei ML, Correia BE, Ban YE, Carrico C, Kalyuzhniy O, Chen L, Schroeter A, Huang PS, McLellan JS, Kwong PD, Baker D, Strong RK, Schief WR. Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold. Science (2011) 334, 373-376.

Bouvignies G, Vallurupalli P, Hansen DF, Correia BE, Lange O, Bah A, Vernon RM, Dahlquist FW, Baker D, Kay LE. Solution structure of a minor and transiently formed state of a T4 lysozyme mutant. Nature (2011) 477, 111-114.

Correia BE, Holmes MA, Huang PS, Strong RK, Schief WR. High-resolution structure prediction of a circular permutation loop. Protein Sci (2011) 20, 1929-1934.

Correia BE, Ban YE, Holmes MA, Xu H, Ellingson K, Kraft Z, Carrico C, Boni E, Sather DN, Zenobia C, Burke KY, Bradley-Hewitt T, Bruhn-Johannsen JF, Kalyuzhniy O, Baker D, Strong RK, Stamatatos L, Schief WR. Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope. Structure (2010) 8, 1116-1126.

Correia BE, Loureiro-Ferreira N, Rodrigues JR, Brito RM. A structural model of an amyloid protofilament of transthyretin. Protein Sci. (2006) 15, 28-32.